Trend-Following Backtester · Guide · backtest 한국어

equity · US

CRISPR Therapeutics AG backtest

10 trend-following strategies were compared on the full daily history of CRISPR Therapeutics AG. 4 beat buy-and-hold CAGR; MACD ranks first by Sharpe, matching the main backtester. The return/drawdown alternative is MACD (CAGR 17.4%, MDD -52.4%).

Data 2016-10-19 ~ 2026-07-31daily bars 2,458 (9.8 years)Costs 0.5%Venue XNASMonthly snapshot 2026-07-31

Results by strategy

4 of 10 beat buy and hold (CAGR 13.3%, drawdown -85.1%).

Sharpe leader (same as main): MACD — CAGR 17.4%, MDD -52.4%, Sharpe 0.57, 48% exposure.

Return/drawdown alternative: MACD — CAGR is 4.1%p higher than buy and hold, while drawdown improves by 32.7%p (CAGR 17.4%, MDD -52.4%, exposure 48%).

The alternative must retain 75% of buy-and-hold CAGR, improve drawdown by at least 20% and 5 percentage points, and stay below 95% exposure; the ranking weights return retention 60% and drawdown improvement 40%.

Strategy · parametersCAGRMDDSharpeCalmarTotalTradesExposure
MACD
fast=17, slow=56, signal=18
17.4%-52.4%0.570.334.8x8848%
Parabolic SAR
step=0.03, maxStep=0.26
15.5%-70.2%0.540.224.1x26948%
Donchian 채널 돌파
entryN=72, exitN=17
13.6%-54.7%0.530.253.5x2626%
SMA 크로스오버
fast=12, slow=131
13.6%-62.1%0.510.223.5x2844%
ADX / DI 방향성
period=25, threshold=20
10.5%-36.9%0.470.292.7x3421%
볼린저 밴드 돌파
n=19, k=3.1
9.0%-31.6%0.470.282.3x2611%
Supertrend
period=19, mult=3
7.8%-82.1%0.390.092.1x6245%
EMA 크로스오버
fast=26, slow=84
6.8%-72.5%0.360.091.9x2645%
Keltner 채널 돌파
emaPeriod=37, atrPeriod=15, mult=3.3
4.8%-62.2%0.300.081.6x2616%
ROC 모멘텀
n=147, threshold=0
3.1%-82.1%0.290.041.4x8849%
Buy and hold13.3%-85.1%0.510.163.4x1100%
1x 10x 2017 2019 2021 2023 2025 MACDBuy and hold
MACD: Solid strategy line versus dashed buy-and-hold line. Log scale.
0% -21% -43% -64% -85% 2017 2019 2021 2023 2025 Buy and holdMACD
MACD maximum drawdown -52.4% (2018-05-30 → 2019-09-24), recovered after 712 days.

Rules of the top strategy

Looks at the gap (MACD) between a short and long average crossing its own signal line.

Method and caveats

Past performance does not guarantee future returns. Parameters were carried forward from the latest full optimization and replayed on this monthly dataset. 0.5% trading costs are included; taxes, slippage and rejected orders are not.
Re-optimize the same period and setupAll asset reports

Read next